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Example-4: Alternative Solid phase peptide synthesis of Gln(Trt)-Ala-Ala-Lys(C18diacid mono-t-butyl-y-Glu(AEEA-AEEA)-OtBu)-Glu(OtBu)-Phe-Ile-Ala-Trp(Boc)-Leu-Val- Arg(pbf)-Gly-Arg (pbf)-Gly-OtBu (fragment-6) Stage-1: Preparation of Fmoc-Gln(Trt)-Ala-Ala-Lys(C18diacid mono-t-butyl-y-Glu (AEEA -AEEA)-OtBu)-OH Step-A: CTC resin (50 grams) was taken in a SPPS reactor and dichloromethane was added and allowed it to swell for 10 minutes

Structural: Damaged basement membrane allows pigment to drop into the dermis, making topical treatments less effective

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Ultrasonography of the liver is usually normal