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The sequence: Ipamorelin binds to GHS-R1a receptors on pituitary somatotroph cells This triggers intracellular signaling The pituitary releases a pulse of growth hormone GH travels throughout the body, exerting direct effects GH also stimulates IGF-1 production in the liver IGF-1 mediates many of growth hormone's anabolic effects Pulsatile vs

doi: 10.1016/s0015-0282(98)00085-5 84 GarridoNKrsselJSRemohJSimnCPellicerA

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