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The lipid-modifying effects appear to be multifactorial, relating to both weight loss and potential direct metabolic actions

( A ) and ( B ) display sagittal and axial views of the brain, highlighting regions with significant group differences using a yellow-orange color scale

doi:10.36849/ JDD.2020.4663

The most common side effects are nausea, diarrhea, and vomiting

The 2020 systematic review by Galeano and colleagues across 34 eligible studies confirmed the mechanism: PDRN promotes physiological tissue repair through salvage-pathway nucleotide recycling and A2A receptor activation [32]