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In posterior segments of the gut (e.g., the cecum and proximal large intestine), gut microbes directly cleave the CN bond of carnitine to release TMA, which subsequently enters the liver through the portal circulation, is converted to TMAO by hepatic flavin monooxygenases (FMOs) [242, 243], and eventually enters the blood circulation [244]

4 Beyond weight loss, researchers are also discovering benefits of GLP-1 drugs in other disease areas

Top-dose weight loss: retatrutide 24.2 percent, tirzepatide 20.9 percent, semaglutide 14.9 percent

Individual genetic variation in sweet taste receptors and glucose-sensing proteins likely explains why some people respond more strongly than others to allulose-driven GLP-1 stimulation