Pickart estimated lethal dose at approximately 22,500 mg for humans (300-fold above effective doses), with animal LD50 studies in mice showing 8 mg per 25g mouse (320 mg/kg, translating to ~22,400 mg for 154 lb human)
Additionally, combining durian with alcohol is particularly concerning
Effects of GLP-1 receptor agonists on reproductive outcomes in women with polycystic ovary syndrome
doi: 10.1177/112067210901900301
370 ROS contribute to tumorigenesis through multiple processes, including causing oxidative DNA damage, genomic instability and inflammatory stress to drive malignant transformation, and acting as a messenger to regulate signaling pathways to support tumor initiation, development, and angiogenesis