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All samples were then digested with either 10 g trypsin (4 h at 37C), or with 400 L solution of 1% formic acid in 10% MeOH with 10 g pepsin (1 h at 37C)

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doi: 10.1016/j.fct.2010.09.030

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found that Receptor-interacting protein 2 (RIP2) can regulate cartilage degradation and oxidative stress in IL-1 -treated chondrocytes by regulating TRAF3 expression and p38-MAPK pathway activation (Pan et al., 2021)