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Additionally, contrasting with clinical results, homocysteine would inhibit both von Willebrand factor and thrombomodulin expression in cultured endothelial cells by affecting the redox-thiol status-regulated transport of newly synthesized glycoproteins in the endoplasmic reticulum
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PE-22-28 inhibits TREK-1 with an IC50 of 0.12 nM, as determined by electrophysiology in HEK293 cells expressing human TREK-1
Exposure to pesticides causes alteration of the inflammatory pathway (Nrf2/NF-kB, MAPKs/PI3K, and Akt/GSK3) reducing NF-E2related factor (Nrf)2, increasing NF-kB, and opening voltage-gated Ca2 + channel of the neurons plasmatic membrane (Silver et al., 2017), leading to oxidative stress, neuronal apoptosis e reduction of serotonin
Battersby AR (1993)
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