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It is associated with a number of human diseases, such as cardiovascular disease (CVD), diabetes, inflammatory disease, aging and cancer (13)

Otx2 binding to perineuronal nets persistently regulates plasticity in the mature visual cortex

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Compared with the control group, this group also exhibited the significantly improved activities of SOD, CAT, and GSH-Px, along with significantly upregulated expression of the antioxidant genes SOD1 and NRF2