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Apart from transcription factors recognizing binding sites close to AREs and non-DNA interacting coregulators, this interactome also harbors pioneering transcription factors, such as FOXA, OCT and GATA family members that facilitate chromatin accessibility so that AR can bind at AREs

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A common DIO2 haplotype composed of the minor C-allele of SNP rs225014 and the common C-allele of SNP rs12885300 was significantly associated with advanced hip OA, as indicated by a higher odds ratio 101,102,103

Covalent aggregates form when monomeric proteins become chemically crosslinked, e.g., though disulfide bonds