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And if you dont, how are you going to avoid regaining all the weight you lost? When appetite and food noise return, patients can feel blindsided, said Holly Wyatt, M.D., an endocrinologist, expert in obesity medicine and professor in the Department of Nutrition Sciences

GLP-1RAs reduce events linked to atherogenic cardiovascular disease (especially ischemic stroke) and also renal outcomes (FLOW trial with semaglutide), with a limited effect on heart failure

81 It also slows stomach emptying, which helps control appetite and reduce food intake

Your doctor may recommend staggered initiation, starting with a low semaglutide dose while maintaining stable testosterone dosing, allowing your body to adapt to the GLP-1 effect

Steady state occurs after four to five consistent weekly doses for semaglutide (about five weeks) and three to four doses for tirzepatide (about four weeks)