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The current European Association for the Study of Diabetes (EASD) and American Diabetes Association (ADA) consensus report recommends stepwise addition of glucose-lowering medications, including the newer classes, i.e

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GIP-induced insulin secretion and consequences for the incretin effect Endogenous GIP affects postprandial plasma glucose excursions and insulin secretion more than endogenous GLP-1, but the hormones contribute additively to postprandial glucose regulation in healthy individuals [4]