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If pancreatitis is suspected, discontinue Ozempic or Rybelsus tablets and initiate appropriate management Diabetic Retinopathy Complications: In a pooled analysis of glycemic control trials, patients reported diabetic retinopathy related adverse reactions during the trial (4.2% with semaglutide tablets and 3.8% with comparator)
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In addition to its use for weight loss, Ozempic is also used as part of a comprehensive weight management plan for some patients
Mechanism of Action: Inhibit Na/K-ATPase intracellular Na Na/Ca exchange intracellular Ca stronger cardiac contraction Vagal tone slow AV node conduction heart rate Effects: Cardiac output Heart rate symptoms of heart failure Examples: Digoxin Digitoxin Clinical Uses: Heart failure with reduced ejection fraction Atrial fibrillation and atrial flutter (rate control) Adverse Effects: Arrhythmias (especially with electrolyte imbalance) GI: nausea, vomiting, diarrhea CNS: confusion, visual disturbances (yellow-green vision) Toxicity risk with hypokalemia, renal impairment, drug interactions Quick Thought Question: How would you monitor a patient for cardiac glycoside toxicity
They will not increase or decrease each other serum concentrations through enzymatic competition
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