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GLP-1/GIP While GLP-1s and GLP-1/GIPs work similarly in the body to promote weight loss, there are two other major differences between these two drugs: FORMULATION GLP-1 medications are GLP-1 receptor agonists, while GLP-1/GIP medications also mimic glucose-dependent insulinotropic polypeptide (GIP)

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Additionally, if gastrointestinal side effects from semaglutide (nausea, vomiting) interfere with the ability to take levothyroxine consistently, medical guidance is needed to maintain thyroid control