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In this regard, it is noteworthy that calorie restriction is associated with increased longevity and reduced insulin/IGF activity in many species (81) albeit GH levels are increased by calorie restriction and fasting (82)

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Keywords: insulin-like growth factor-1, chondrocyte, cartilage development, osteoarthritis, rabbit Introduction Osteoarthritis (OA) is a disorder characterized by joint pain and disability that is associated with deterioration in quality of life

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