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Check for drug interactions - Some prescription medicines, like metformin, can deplete B12 over time

doi: 10.1146/annurev.psych.52.1.471 4

| Target Concentration | BAC Water to Add | Dose per 10 units on syringe | |---------------------|-----------------|------------------------------| | 10mg/ml | 3.0ml | 1.0mg | | 15mg/ml | 2.0ml | 1.5mg | | 6mg/ml | 5.0ml | 0.6mg | **Best for:** Patients on 4-12mg weekly doses who want the best cost-per-milligram value

It is also worth noting that nutritional needs may change over time for example, during pregnancy, illness, or ageing and supplementation regimens should be reviewed accordingly

Early intervention before scarring develops offers the best outcomes