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This process is self-reinforcing: inflammation-derived oxidative stress promotes further ferroptosis, while dying ferroptotic cells release DAMPs that activate surrounding structural and immune cells, intensifying the inflammatory response ( 6.2 Classical and non-classical pathways of ferroptosis regulation The regulation of ferroptosis in the asthmatic airway involves both canonical and alternative mechanisms that determine cellular susceptibility to this form of cell death

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Molecular structure of DPP-4 Initially described by Hopsu-Havu & Glenner in 1966 [25], DPP-4 is a dimeric 240-kDa glycoprotein composed of two 120-kDa subunits and encoded by a gene located in chromosome 2q24 [25]