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First, we conducted a similar interrupted time-series analysis using data from August 2014 to July 2018, excluding the period affected by the tobacco price increase in October 2018

In the documented protocol, someone tolerating the compound well and progressing at 7.5 or 10 mg has no requirement to escalate further

The accumulation of free cholesterol in LSEC endolysosomes disrupted Rab7 membrane trafficking and impaired the transport of TLR9 from late endosomes to lysosomes, enhancing activation of the TLR9/inflammasome pathway mediating APAP-induced liver injury

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