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Supplements and Down syndrome There are mixed data regarding whether people with Down syndrome require the active forms (versus inactive forms) of vitamin B12 and folate when taking a supplement

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Primary Care Guidelines for B12 and Folate Testing Indications for B12 and Folate Testing No need to check B12 levels in patient on parenteral B12 treatment (they will always be high) There is no indication to check GPA or INF purely because of family history of autoimmune disease or hypothyroidism Care should be taken when prescribing folic acid alone If folic acid is given to a patient who is actually b12 deficient, this may precipitate irreversible neurological complications References 1

"I'd say maybe only a handful of people at most in the last 10 years have I ever actually thought would benefit from B12 injections." As to why some physicians would be needlessly prescribing B12 shots, he said, "It may be just habit

Pregnancy and breastfeeding are off the protocol