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Patients with self-reported changes in bodyweight 5 kg within 90 days before screening and previous obesity treatment were excluded

These effects were likely an adaptive response secondary to the pharmacological effect of semaglutide on food consumption and body weight

Tirzepatide dosing schedule Tirzepatide follows a dose escalation from 2.5 mg to the maximum approved dose of 15 mg, with increases occurring every four weeks

Under normal circumstances, fatty foods trigger the release of cholecystokinin (CCK) and other hormones that slow gastric emptying to allow adequate time for fat digestion and absorption in the small intestine