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Practical tapers often hold each lower step for 8 to 12 weeks, although that schedule has not been tested directly

In fact, research shows it can cause nearly 14% weight loss in a little over a year, alongside diet and exercise

One concern noted in legal documents is that original labels lacked warnings of serious side effects, including severe gastrointestinal issues and other dangerous conditions

This has led to 57% of employers in the large firm category to refuse coverage of GLP-1 drugs for weight loss, while others are implementing strict controls on access

In addition to these primary mechanisms of action, studies have also shown that GLP-1 RAs can increase insulin sensitivity by reducing inflammation.25 When all of these actions combine, you end up with a decreased appetite between meals, a desire to eat less during meals, and a more balanced insulin response to the food that you eat