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Steps to check your coverage before ordering through a lab: Ask your physician whether your clinical situation qualifies as a covered indication Call your insurer and ask specifically about CPT code 81291 (MTHFR Mutation Analysis) Request a prior authorization if required by your plan before the test is ordered Confirm the lab is in-network LabCorp and Quest are widely covered but verify with your specific plan Direct-to-consumer at-home tests like PlexusDx are not covered by standard health insurance regardless of indication