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Insight into vitamin B6-dependent epilepsy due to PLPBP (previously PROSC) missense mutations

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Indications: Treatment of orthostatic hypotension in adult patients with symptomatic neurogenic orthostatic hypotension (nOH) caused by: Parkinson's disease multiple system atrophy pure autonomic failure) dopamine beta-hydroxylase deficiency non-diabetic autonomic neuropathy Pharmacokinetics: administered orally converted by DOPA decarboxylase into norepinephrine Side Effects: A new drug