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105 However, both the Phase 3 PWS trial and a Phase 2 trial in people with severe obesity complicated by type 2 diabetes were blocked early following the death of two PWS patients due to pulmonary emboli

Interestingly, high GPX1 and GPX4 expression are correlated to poor prognosis in patients suffering AML, suggesting that targeting one or both proteins could be of high potential therapeutic value [36]

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