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And although the rate roughly doubled from 2003 to 2009, it has remained level since 2012

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This is crucial for species adaptation because it has been shown that maternal steroid hormones are rapidly metabolized by fetal-placental tissues to shape the fetal brain and modulate neurodevelopment and behavior as an adaptive consequence to the exposure of maternal steroid hormones, and independently of its classical effects mediated by their nuclear steroid hormone receptors (196)