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Wrong hormones The WHI used Premarin (conjugated equine estrogens from horse urine) plus Provera (synthetic progestin) not bioidentical hormones Wrong timing The average participant was 63 years old more than a decade past menopause

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Two specific enzyme classes do most of the damage: Aminopeptidases chew peptides from the N-terminus (the front amino group end) Carboxypeptidases chew peptides from the C-terminus (the back carboxyl group end) Both are abundant in blood, in tissue, and in the GI tract

A conditional Met -transgenic mouse was also generated, showing that the enhancement of MET levels in neurons selectively delays the disease onset in ALS mice models, prolonging lifespan, retarding motor neuron loss, and ameliorating motor performance (Genestine et al., 2011)