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Age, sex, and APOE 4 carrier status were included because they are well-established risk factors for AD

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Nature Reviews Molecular Cell Biology, 22 (2), 119141

The identified metabolites were annotated using the KEGG database ( the Human Metabolome Database (HMDB) database ( and the Lipid Metabolites and Pathways Strategy (LIPIDMaps) database ( PCA and PLS-DA were performed after transforming raw data using metaX in R software