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Specifically, methylene tetrahydrofolate (THF) dehydrogenases catalyze the oxidation of 5,10-methylene-THF to form 10-formyl-THF, which is subsequently oxidized to CO 2 with concomitant NADPH production by 10-formyl-THF dehydrogenases (55)

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Berberine activates AMP-activated protein kinase, improves insulin sensitivity at the cellular level, and may enhance gut microbiota composition to support glucose control through a distinct metabolic pathway