This provides sustained, pharmacologic activation of the GLP-1 receptors in a way that goes beyond normal physiology
Numerous signaling pathways, such as cyclooxygenase 2 (COX-2), mammalian target of rapamycin (mTOR), mitogen-activated protein kinase (MAPK) signaling, phosphoinositide 3 kinase (PI3K), and the GATA4/p62-mediated autophagy pathways result in the stimulation of NF-B and/or C/EBP pathways, which in turn regulate the SASP secretome (81, 82)
Designing around this uncertainty requires conservative dosing, staggered administration, and robust behavioral monitoring
Cell Death Dis 15 , 556 (2024)
Everybodys body is a little different in terms of how they respond to these medications, and some kids may experience pretty profound appetite suppression so we have to do a lot of checking-in with them, said Hampl