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PMID: 26604952

"It's preliminary, but you can see that countries that have more ergothioneine in their diets, countries like France and Italy, also have lower incidences of neurodegenerative diseases, while people in countries like the United States, which has low amounts of ergothioneine in the diet, have a higher probability of diseases like Parkinson's Disease and Alzheimer's," said Beelman

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This means they don't undergo the same rigorous testing as standard pharmaceuticals

Interaction with Anti-Platelet Drugs Few studies also investigated the interaction between metformin and anti-platelet drugs, such as aspirin and clopidogrel