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Temperature excursions above 8C cause irreversible protein denaturationthis isn't a potency reduction, it's complete inactivation

In both animal models and controlled human studies, DSIP has been associated with modulation of endogenous sleep-regulating systems rather than direct sedative activity, supporting its classification as a neuromodulator rather than a pharmacological hypnotic agent [2]

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It has a low molecular weight and it doesnt bind to the extracellular matrix, being able to travel long distances through the tissues in the human body