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The researchers applied water soluble black ink to the plantar surfaces of the rats hindpaws prior to walking down the walkway from its entrance and into the shelter

Key findings include: Upregulation of VEGFR2 expression and internalization in endothelial cells Activation of the VEGFR2-Akt-eNOS signaling cascade Enhanced endothelial cell proliferation and tube formation Improved collateral circulation in ischemic injury models The peptides pro-angiogenic effects appear particularly relevant in healing scenarios where blood supply restoration is critical for tissue recovery

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doi: 10.1126/science.1183021 75 WallaceKL

[34] Alterations of membrane contacts have been observed in various diseases