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The 500-Dalton Ceiling Intact human skin allows passive transepidermal absorption of molecules under approximately 500 daltons

10.1056/NEJMoa066224 62 KanoskiS

Moreover, interaction tests indicated that the associations between vitamin B2 intake and osteoporosis was modified by the variable of total MET, with the risk for OP reduced more pronounced in the subgroup of insufficiently active individuals as the increment of vitamin B2 intake (P interaction = 0.0364, Table 5)