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A denial does not always end the process because appeals and alternative pathways may still help

In major clinical trials, such as the landmark STEP 1 trial published in the New England Journal of Medicine , a once-weekly injection of semaglutide 2.4 mg resulted in an average body weight reduction of roughly 14.9% over 68 weeks

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Formulation variations - Compounded versions may differ in inactive ingredients (preservatives, stabilizers, pH adjusters) from brand-name products, which can affect tolerability for some individuals