An IM injection delivers medicine directly into a muscle rather than under the skin, allowing faster absorption and avoiding some of the delays or limits of oral or subcutaneous routes
The reviewer CY declared a shared affiliation with the authors LQ, HK, LW, YL, MZ, FZ, ZX, XyL, ZC, and LL to the handling editor at the time of review
Patients may need to manage this by staying hydrated and eating smaller, more frequent meals
Key hypothalamic centers, including the arcuate and paraventricular nuclei, exhibit high GLP-1 receptors expression, which coordinate peripheral metabolic cues to modulate feeding behavior and energy balance [34]
Berobenatide had a favorable risk-benefit profile with very few adverse events despite the fact that dose deescalation was not allowed in the study. The safety profile of berobenatide in VESPER-2 was consistent with the GLP-1 RA class, and no new safety signals were identified