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For example, several studies using proton magnetic resonance spectroscopy have reported reduced levels of N -acetyl aspartate, a marker of impaired mitochondrial energy production, in the brains of bipolar disorder patients compared with healthy controls [121,122,123,124,125]

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The weight and safety estimates had moderate certainty because of the wide confidence interval

Not a single-target drug that hammers one pathway and creates side effects elsewhere, but multi-mechanism molecules that can address inflammation, barrier repair, and microbial defense at the same time

232 Long-term follow-up studies will help clarify whether this potential safety signal merits further investigation