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Another study further demonstrated that the FAD/NAD(P)H-binding site of FSP1 is evolutionarily conserved among NADH quinone reductases, and targeting this region enabled the development of viFSP1, a species-independent inhibitor that interacts with the NAD(P)H-binding pocket of FSP1 121

The current limitation of our assay is applicability to transfectable cell lines, and higher expression of plasmid-encoded sensors relative to endogenous glucose-6-phosphate dehydrogenase

For example, the TCMBank database offers comprehensive data on 9,192 medicinal materials, 61,966 components, and 15,179 targets, which forms a solid foundation for applying machine learning algorithms in target discovery [241]

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The acetyl group provides a plausible protective mechanism