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Notably, the ferroptosis inhibitor Ferrostatin-1 exacerbated CGAs toxicity, while the inducer Erastin attenuated it (Supplementary Figure S2C), suggesting that the profound iron deficiency we describe disrupts fundamental metabolism in a manner distinct from, and prior to, the execution of classical ferroptosisa pathway CGA has been shown to inhibit in other contexts via Nrf2/GPX4 activation (Yang et al., 2025)

These combined effects help regulate blood sugar and reduce appetite, promoting a feeling of fullness

Reduced Stress and Anxiety Modulates cortisol release May reduce sympathetic nervous system overactivation Anecdotal reports of calmness without fatigue 3

Lina lets users keep dose dates and notes near the weight trend so the discussion is grounded in a timeline

They include: Dietary Changes: Adopting a low-sodium diet can significantly reduce fluid retention, which is a common symptom of CHF