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WADA (World Anti-Doping Agency): IGF-1 and all analogs, including LR3, are prohibited substances under the S2 category (Peptide Hormones, Growth Factors, and Related Substances)

Additionally, your L-cells contain specific receptors that determine how efficiently they respond to food signals, which is partly determined by your genetic makeup

Int J Clin Pract 70(8):649656 Yaribeygi H, Farrokhi FR, Abdalla MA, Sathyapalan T, Banach M, Jamialahmadi T, et al (2021) The effects of glucagon-like peptide-1 receptor agonists and dipeptydilpeptidase-4 inhibitors on blood pressure and cardiovascular complications in diabetes

Although these compounds are understandable, well tolerated, and tend to have positive outcomes, variability among people is common depending upon age, medical history, hormone levels and health purpose

K., Calvaresi N., Carvelli L., Bastone A., et al