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No formal FDA rule had been published as of that date

If the application was forgotten A double dose should not be used if the previous dose has been forgotten

Came with everything needed, syringes, alcohol pads, arrived on ice

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The post-opening discard period exists because: Sterility can no longer be fully guaranteed after first puncture Preservatives slow microbial growth but do not eliminate contamination risk Risk of contamination increases with repeated vial access For this reason, healthcare and laboratory settings typically follow a fixed discard timeframe (commonly 28 days), unless otherwise specified by the manufacturer