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That means they can only be prescribed off-label, which insurers often dont cover and can cost patients as much as $5,000 a month, he said said

When compared to GLP1RAs, which improve insulin sensitivity primarily through weight reduction, a post-doc regression analysis of HOMA2-IR indicates that only 2030% of the improvement in insulin sensitization observed with tirzepatide is due to weight loss (NCT03951753) [77, 78]

It is a medical treatment, not a miracle cure

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