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PMID 40196945

Hall says there are several important insights from this study

Induction of hypothalamic Sirt1 leads to cessation of feeding via agouti-related peptide

Patients who use the appetite suppression window to build sustainable dietary habits , establish regular exercise routines, and address the psychological drivers of overeating have dramatically better outcomes when medication stops or decreases

Try sipping small amounts frequently rather than drinking large volumes at once, choose room temperature fluids instead of very cold water, and consider electrolyte solutions, herbal teas (ginger or peppermint), clear broths, or water-rich foods like watermelon