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References Sisley S, Gutierrez-Aguilar R, Scott M, DAlessio DA, Sandoval DA, Seeley RJ

The physiologic significance of these numerous actions has not been established.25 The pattern of PYY secretion in response to a meal raises the hypothesis that it may play a role as physiologic satiety signal, acting in terminating the meal and stimulating coordinated gastrointestinal responses in order to aid digestion and absorption

Weight loss varies by individual and program, but many patients lose 12 pounds per week

Current research is focused on validating these predictive models in diverse populations and expanding biomarker panels to include polygenic risk scores and proteomic signatures