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GIP receptor antagonists: Although agonism is currently dominant in approved therapies, antagonists are being explored in animal models for obesity, because blockade of GIP signalling may limit lipid storage and adiposity under certain conditions

Some studies suggest small benefits in selected groups, while others show little or no effect

A few to approach carefully: Calcium: High-dose calcium supplements taken without medical guidance can interfere with iron absorption and cause GI discomfort

There are crackdown efforts: The US Food and Drug Administration says people should buy their drugs from licensed pharmacies, with valid prescriptions

This approach allows patients to achieve their weight loss goals while building sustainable healthy habits