For the summary outcomes, we computed the estimates of the random effects using restricted maximum likelihood to estimate the heterogeneity variance, since we assumed clinical variability between the studies
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Patients at higher risk of intolerance, including older adults and patients with comorbid anxiety, may tolerate treatment better with lower-than-usual starting doses and gradual titration
Despite substantial progress, major questions remain unresolved particularly regarding the integration of ROS signaling with other secondary messengers, such as Ca 2 , nitric oxide, and phytohormones, under combined or fluctuating stress conditions
Optionally, you can open the capsules and mix the contents with water