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Adverse reactions to drugs Medicines guidance (BNF)

Hormonal imbalance: Elevated male hormones (androgens) alter fat storage, causing fat to accumulate primarily in the abdomen

The drug companies believe that hitting more receptors induces better weight-loss effects, which does appear to be true, but when it comes to what this is doing across different immune populations, downstream signaling can be completely changed by adding on these extra agonists, she says