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Because this formula actively lowers blood glucose and sensitizes insulin receptors, combining it with prescription antidiabetic drugs (such as Metformin, insulin, or sulfonylureas) can increase the risk of hypoglycemia (dangerously low blood sugar)

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People who were taking them tended to lose a little bit of weight and so the drug companies that manufactured them wondered if people taking larger doses would lose more weight (at least short term.) They did, and then applied for and received FDA approval here in the US specifically for weight loss