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Additionally, increased serum iron levels caused by frequent hemolysis may play a role in immune modulation, as several studies have linked hyperferremia with serious infection in humans, a concept termed nutritional immunity (7174)

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Low-dose protocols (0.250.5mg daily) are derived from studies where systemic copper peptide administration at 24 mcg/kg demonstrated follicle-stimulating activity without elevating serum copper above the normal range (70140 mcg/dL)

Mangum CL, Patel DP, Jafek AR, et al