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TABLE 9 comparative results (normalized by area) for related substances (2) Other indicators Sample preparation: pilot samples (production lot: P-110201), three lots of process verification samples (production lot: YJ110401, YJ110402, and YJ110403), and commercial products (production lot: 31002)

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Nature 630 , 984993 (2024)

Chronic hypercortisolism exposure has particularly significant damaging effects on the hippocampus, leading to neuronal dendritic atrophy, reduced synaptic density, and neurogenesis inhibition, resulting in an average 810% reduction in hippocampal volume in depression patients ( Cortisol damages the CNS and has widespread effects on the gut