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The exact mechanism remains unclear, but several possibilities have emerged: Autonomic Modulation: GLP-1 agonists may reduce parasympathetic (vagal) tone or enhance sympathetic drive, leading to a faster resting heart rate

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A separate JAMA Health Forum analysis found semaglutide would need a very large price reduction to meet common cost-effectiveness thresholds, and tirzepatide would also require further price cuts to become cost-effective in that model