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It is important to note that a recent study has demonstrated a significant upregulation of NRF2, HMOX-1 and NQO-1 mRNA expression, as well as an increase in HMOX-1 and NQO-1 protein levels in the spinal cord of ALS patients (Lastres-Becker et al., 2022)

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After filtration, the solvent was removed in vacuo and the residue was dissolved in NaOH aqueous solution (1 M), and washed with DCM (3 30 mL)

Quinolinium ring system: core structure for interacting with the enzyme's active site

A primary deficiency means that there is a genetic disorder that would cause the body to not produce sufficient levels of carnitine